James Ryan, MD

Associate Professor of Medicine, Gastroenterology
Medicine
+1 415 750-2104 ext. 3462

NK cells, Immunology, Hepatitis C, Inflammatory Bowel Disease

Publications: 

Surgical site complications in open pronation-abduction ankle fracture-dislocations with medial tension failure wounds.

Journal of orthopaedic trauma

Martin CW, Ryan JC, Bullock TS, Cabot JH, Makhani AA, Griffin LP, Zelle BA

The Fate of the Uninsured Ankle Fracture: Significant Delays in Treatment Result in Increased Risk of Surgical Site Infection.

Journal of orthopaedic trauma

Zelle BA, Johnson TR, Ryan JC, Martin CW, Cabot JH, Griffin LP, Bullock TS, Ahmad F, Brady C, Shah K

Skin closure with surgical staples in ankle fractures: a safe and reliable method.

International orthopaedics

Prabhakar G, Bullock TS, Martin CW, Ryan JC, Cabot JH, Makhani AA, Griffin LP, Shah K, Zelle BA

SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.

Frontiers in immunology

Fernandes S, Srivastava N, Sudan R, Middleton FA, Shergill AK, Ryan JC, Kerr WG

Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.

Journal of immunology (Baltimore, Md. : 1950)

Méndez-Lagares G, Lu D, Chen C, Terrault N, Segal MR, Khalili M, Monto A, Shen H, Manos MM, Lanier LL, Ryan JC, McCune JM, Hartigan-O'Connor DJ

NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration.

Experimental and molecular pathology

Vadstrup K, Galsgaard ED, Jensen H, Lanier LL, Ryan JC, Chen SY, Nolan GP, Vester-Andersen MK, Pedersen JS, Gerwien J, Jensen T, Bendtsen F

P-305 SHIP1 Deficiency in Adult Inflammatory Bowel Disease Is Associated with Severe Crohn's Disease and Peripheral T Cell Reduction.

Inflammatory Bowel Diseases

Sandra Fernandes Denney, Neetu Srivastava, Frank Middleton, James Ryan, William Kerr

Improved Survival Among all Interferon-a-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders.

Digestive diseases and sciences

Cozen ML, Ryan JC, Shen H, Cheung R, Kaplan DE, Pocha C, Brau N, Aytaman A, Schmidt WN, Pedrosa M, Anand BS, Chang KM, Morgan T, Monto A

P-176 SHIP1 Deficiency in Human IBD.

Inflammatory Bowel Diseases

William Kerr, Sandra Fernandes, Frank Middleton, John Chisholm, James Ryan

P-177 Altered SHIP1-Protein Degradation in a Subset of IBD Patients.

Inflammatory Bowel Diseases

Sandra Fernandes, James Ryan, Frank Middleton, John Chisholm, William Kerr

Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer.

Gastrointestinal endoscopy

Shergill AK, Conners EE, McQuaid KR, Epstein S, Ryan JC, Shah JN, Inadomi J, Somsouk M

Microarray applications to understand the impact of exposure to environmental contaminants in wild dolphins (Tursiops truncatus).

Marine genomics

Mancia A, Abelli L, Kucklick JR, Rowles TK, Wells RS, Balmer BC, Hohn AA, Baatz JE, Ryan JC

Machine learning approaches to investigate the impact of PCBs on the transcriptome of the common bottlenose dolphin (Tursiops truncatus).

Marine environmental research

Mancia A, Ryan JC, Van Dolah FM, Kucklick JR, Rowles TK, Wells RS, Rosel PE, Hohn AA, Schwacke LH

Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.

HPB : the official journal of the International Hepato Pancreato Biliary Association

Ho EY, Cozen ML, Shen H, Lerrigo R, Trimble E, Ryan JC, Corvera CU, Monto A

Monocyte activation by interferon a is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.

The Journal of infectious diseases

Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM

O-018 SHIP1-deficiency in a Subset of IBD Patients.

Inflammatory Bowel Diseases

Sandra Fernandes, James Ryan, William Kerr

Transcriptomic responses of juvenile Pacific whiteleg shrimp, Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia.

Physiological genomics

Rathburn CK, Sharp NJ, Ryan JC, Neely MG, Cook M, Chapman RW, Burnett LE, Burnett KG

Impaired lymphocyte reactivity measured by immune function testing in untransplanted patients with cirrhosis.

Clinical and vaccine immunology : CVI

Yee RM, Lehil MS, Rongey C, Shen H, Cozen ML, Monto A, Ryan JC

Health status, infection and disease in California sea lions (Zalophus californianus) studied using a canine microarray platform and machine-learning approaches.

Developmental and comparative immunology

Mancia A, Ryan JC, Chapman RW, Wu Q, Warr GW, Gulland FM, Van Dolah FM

Transcriptome remodeling associated with chronological aging in the dinoflagellate, Karenia brevis.

Marine genomics

Johnson JG, Morey JS, Neely MG, Ryan JC, Van Dolah FM

The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages.

Journal of leukocyte biology

Shegarfi H, Dai KZ, Daws MR, Ryan JC, Vaage JT, Rolstad B, Naper C

The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells.

European journal of immunology

Shegarfi H, Dai KZ, Inngjerdingen M, Ryan JC, Vaage JT, Rolstad B, Naper C

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

Proceedings of the National Academy of Sciences of the United States of America

Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE

Response.

Gastrointestinal endoscopy

Amandeep K. Shergill, Krishna R. Asundi, Alan Barr, Janak N. Shah, James C. Ryan, Kenneth R. McQuaid, David Rempel

Pinch force and forearm-muscle load during routine colonoscopy: a pilot study.

Gastrointestinal endoscopy

Shergill AK, Asundi KR, Barr A, Shah JN, Ryan JC, McQuaid KR, Rempel D

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.)

Maher JJ, Leon P, Ryan JC

Corrigendum to “A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus” [Drug Alcohol Depend. 93(1–2) (2008) 148–154].

Drug and Alcohol Dependence

Sue L. Currie, James C. Ryan, Daniel Tracy, Teresa L. Wright, Sally George, Rosemary McQuaid, Michael Kim, Hui Shen, Alexander Monto

Endoscopic Evaluation and Management of Colonic Postpolypectomy Hemorrhage.

Gastrointestinal endoscopy

Joseph Chen, Amandeep K. Shergill, Kenneth R. Mcquaid, James C. Ryan, Janak N. Shah

Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.

Toxicological sciences : an official journal of the Society of Toxicology

Morey JS, Ryan JC, Bottein Dechraoui MY, Rezvani AH, Levin ED, Gordon CJ, Ramsdell JS, Van Dolah FM

Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid.

Genomics

Twiner MJ, Ryan JC, Morey JS, Smith KJ, Hammad SM, Van Dolah FM, Hess P, McMahon T, Satake M, Yasumoto T, Doucette GJ

A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus.

Drug and Alcohol Dependence

Currie SL, Ryan JC, Tracy D, Wright TL, George S, McQuaid R, Kim M, Shen H, Monto A

Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.

Neurotoxicology

Ryan JC, Bottein Dechraoui MY, Morey JS, Rezvani A, Levin ED, Gordon CJ, Ramsdell JS, Van Dolah FM

Evaluation of Distal Upper Extremity Musculoskeletal Load During Routine Colonoscopy.

Gastrointestinal endoscopy

Amandeep K. Shergill, Krishna R. Asundi, Alan Barr, Janak N. Shah, James C. Ryan, Kenneth R. Mcquaid, David Rempel

Prospective Randomized Trial of Standard Versus Magnetic Endoscope Imaging Colonoscopes On Patient Tolerance of Unsedated Colonoscopy.

Gastrointestinal endoscopy

Amandeep K. Shergill, Arnel Deleon, James C. Ryan, Kenneth R. Mcquaid, Janak N. Shah

The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats.

Journal of immunology (Baltimore, Md. : 1950)

Kveberg L, Bäck CJ, Dai KZ, Inngjerdingen M, Rolstad B, Ryan JC, Vaage JT, Naper C

Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid.

Neuroscience

Ryan JC, Morey JS, Ramsdell JS, Van Dolah FM

Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs.

Immunogenetics

Saether PC, Westgaard IH, Flornes LM, Hoelsbrekken SE, Ryan JC, Fossum S, Dissen E

Killer cell lectin-like receptors and the natural killer cell gene complex.

Advances in experimental medicine and biology

Nylenna O, Flornes LM, Westgaard IH, Woon PY, Naper C, Vaage JT, Gauguier D, Ryan JC, Dissen E, Fossum S

The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.

European journal of immunology

Nylenna O, Naper C, Vaage JT, Woon PY, Gauguier D, Dissen E, Ryan JC, Fossum S

Activating and inhibitory Ly49 receptors modulate NK cell chemotaxis to CXC chemokine ligand (CXCL) 10 and CXCL12.

Journal of immunology (Baltimore, Md. : 1950)

Inngjerdingen M, Rolstad B, Ryan JC

Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat.

Journal of immunology (Baltimore, Md. : 1950)

Hoelsbrekken SE, Nylenna Ø, Saether PC, Slettedal IO, Ryan JC, Fossum S, Dissen E

Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands.

Journal of immunology (Baltimore, Md. : 1950)

Naper C, Hayashi S, Kveberg L, Niemi EC, Lanier LL, Vaage JT, Ryan JC

Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c).

European journal of immunology

Naper C, Hayashi S, Joly E, Butcher GW, Rolstad B, Vaage JT, Ryan JC

Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Naper C, Hayashi S, Løvik G, Kveberg L, Niemi EC, Rolstad B, Dissen E, Ryan JC, Vaage JT

A visual pigment expressed in both rod and cone photoreceptors.

Neuron

Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK

Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.

European journal of immunology

Daws MR, Lanier LL, Seaman WE, Ryan JC

Characterization and molecular cloning of rat C1qRp, a receptor on NK cells.

European journal of immunology

Løvik G, Vaage JT, Dissen E, Szpirer C, Ryan JC, Rolstad B

Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d).

The Journal of experimental medicine

Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE

Molecular characterization of the rat NK cell receptor 2B4.

Molecular immunology

Kumaresan PR, Stepp SE, Verrett PC, Chuang SS, Boles KS, Lai WC, Ryan JC, Bennett M, Kumar V, Mathew PA

Functional analysis of natural killer cell receptors in the RNK-16 rat leukemic cell line.

Methods in molecular biology (Clifton, N.J.)

Ryan JC, Niemi EC, Nakamura MC

Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor.

Journal of immunology (Baltimore, Md. : 1950)

Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC

Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets.

The Journal of experimental medicine

Eriksson M, Leitz G, Fällman E, Axner O, Ryan JC, Nakamura MC, Sentman CL

Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity.

The Journal of experimental medicine

Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE

Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.

The Journal of experimental medicine

Wakil AE, Wang ZE, Ryan JC, Fowell DJ, Locksley RM

The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.

Journal of immunology (Baltimore, Md. : 1950)

Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K

Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.

The Journal of experimental medicine

Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT

Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells.

Journal of immunology (Baltimore, Md. : 1950)

Naper C, Ryan JC, Nakamura MC, Lambracht D, Rolstad B, Vaage JT

Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.

Journal of immunology (Baltimore, Md. : 1950)

Houchins JP, Lanier LL, Niemi EC, Phillips JH, Ryan JC

Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.

The Journal of experimental medicine

Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC

Divergent functions of lectin-like receptors on NK cells.

Immunological reviews

Ryan JC, Seaman WE

NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.

The Journal of experimental medicine

Ryan JC, Niemi EC, Nakamura MC, Seaman WE

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

Journal of immunology (Baltimore, Md. : 1950)

Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A

Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules.

Journal of immunology (Baltimore, Md. : 1950)

Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE

NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium.

Journal of immunology (Baltimore, Md. : 1950)

Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE

cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.

Journal of immunology (Baltimore, Md. : 1950)

Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE