
Associate Professor of Medicine, Gastroenterology
M_MED-VAMC-GAST
+1 415 750-2104 ext. 3462
NK cells, Immunology, Hepatitis C, Inflammatory Bowel Disease
Publications
Hepatocellular carcinoma after direct-acting antivirals for hepatitis C is associated with KIR-HLA types predicting weak NK cell-mediated immunity.
European journal of immunology
Surgical site complications in open pronation-abduction ankle fracture-dislocations with medial tension failure wounds.
Journal of orthopaedic trauma
The Fate of the Uninsured Ankle Fracture: Significant Delays in Treatment Result in Increased Risk of Surgical Site Infection.
Journal of orthopaedic trauma
Skin closure with surgical staples in ankle fractures: a safe and reliable method.
International orthopaedics
SHIP1 Deficiency in Inflammatory Bowel Disease Is Associated With Severe Crohn's Disease and Peripheral T Cell Reduction.
Frontiers in immunology
Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats.
Journal of immunology (Baltimore, Md. : 1950)
Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success.
Journal of immunology (Baltimore, Md. : 1950)
NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration.
Experimental and molecular pathology
P-305 SHIP1 Deficiency in Adult Inflammatory Bowel Disease Is Associated with Severe Crohn's Disease and Peripheral T Cell Reduction.
Inflammatory Bowel Diseases
IL-33 promotes growth and liver metastasis of colorectal cancer in mice by remodeling the tumor microenvironment and inducing angiogenesis.
Molecular carcinogenesis
Improved Survival Among all Interferon-a-Treated Patients in HCV-002, a Veterans Affairs Hepatitis C Cohort of 2211 Patients, Despite Increased Cirrhosis Among Nonresponders.
Digestive diseases and sciences
P-176 SHIP1 Deficiency in Human IBD.
Inflammatory Bowel Diseases
P-177 Altered SHIP1-Protein Degradation in a Subset of IBD Patients.
Inflammatory Bowel Diseases
Protective association of colonoscopy against proximal and distal colon cancer and patterns in interval cancer.
Gastrointestinal endoscopy
Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin.
BMC medical genomics
Microarray applications to understand the impact of exposure to environmental contaminants in wild dolphins (Tursiops truncatus).
Marine genomics
Structural brain abnormalities in patients with inflammatory illness acquired following exposure to water-damaged buildings: a volumetric MRI study using NeuroQuant®.
Neurotoxicology and teratology
Machine learning approaches to investigate the impact of PCBs on the transcriptome of the common bottlenose dolphin (Tursiops truncatus).
Marine environmental research
Expanded use of aggressive therapies improves survival in early and intermediate hepatocellular carcinoma.
HPB : the official journal of the International Hepato Pancreato Biliary Association
Monocyte activation by interferon a is associated with failure to achieve a sustained virologic response after treatment for hepatitis C virus infection.
The Journal of infectious diseases
O-018 SHIP1-deficiency in a Subset of IBD Patients.
Inflammatory Bowel Diseases
Transcriptomic responses of juvenile Pacific whiteleg shrimp, Litopenaeus vannamei, to hypoxia and hypercapnic hypoxia.
Physiological genomics
Impaired lymphocyte reactivity measured by immune function testing in untransplanted patients with cirrhosis.
Clinical and vaccine immunology : CVI
Health status, infection and disease in California sea lions (Zalophus californianus) studied using a canine microarray platform and machine-learning approaches.
Developmental and comparative immunology
Transcriptome remodeling associated with chronological aging in the dinoflagellate, Karenia brevis.
Marine genomics
Development of a measure of work motivation for a meta-theory of motivation.
Psychological reports
The rat NK cell receptors Ly49s4 and Ly49i4 recognize nonclassical MHC-I molecules on Listeria monocytogenes-infected macrophages.
Journal of leukocyte biology
The activating rat Ly49s5 receptor responds to increased levels of MHC class Ib molecules on Listeria monocytogenes-infected enteric epithelial cells.
European journal of immunology
Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid.
Neuroscience letters
Gene expression profiling in brain of mice exposed to the marine neurotoxin ciguatoxin reveals an acute anti-inflammatory, neuroprotective response.
BMC neuroscience
Defining the neurotoxin derived illness chronic ciguatera using markers of chronic systemic inflammatory disturbances: a case/control study.
Neurotoxicology and teratology
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
Proceedings of the National Academy of Sciences of the United States of America
Response.
Gastrointestinal endoscopy
Pinch force and forearm-muscle load during routine colonoscopy: a pilot study.
Gastrointestinal endoscopy
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.)
Corrigendum to “A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus” [Drug Alcohol Depend. 93(1–2) (2008) 148–154].
Drug and Alcohol Dependence
Endoscopic Evaluation and Management of Colonic Postpolypectomy Hemorrhage.
Gastrointestinal endoscopy
Liver genomic responses to ciguatoxin: evidence for activation of phase I and phase II detoxification pathways following an acute hypothermic response in mice.
Toxicological sciences : an official journal of the Society of Toxicology
A prospective study to examine persistent HCV reinfection in injection drug users who have previously cleared the virus.
Drug and Alcohol Dependence
Transcriptional profiling of whole blood and serum protein analysis of mice exposed to the neurotoxin Pacific Ciguatoxin-1.
Neurotoxicology
Evaluation of Distal Upper Extremity Musculoskeletal Load During Routine Colonoscopy.
Gastrointestinal endoscopy
Prospective Randomized Trial of Standard Versus Magnetic Endoscope Imaging Colonoscopes On Patient Tolerance of Unsedated Colonoscopy.
Gastrointestinal endoscopy
Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR.
Biological procedures online
The novel inhibitory NKR-P1C receptor and Ly49s3 identify two complementary, functionally distinct NK cell subsets in rats.
Journal of immunology (Baltimore, Md. : 1950)
Gene expression in Florida red tide dinoflagellate Karenia brevis: analysis of an expressed sequence tag library and development of DNA microarray.
Marine biotechnology (New York, N.Y.)
Two structurally related rat Ly49 receptors with opposing functions (Ly49 stimulatory receptor 5 and Ly49 inhibitory receptor 5) recognize nonclassical MHC class Ib-encoded target ligands.
Journal of immunology (Baltimore, Md. : 1950)
Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs.
Immunogenetics
Killer cell lectin-like receptors and the natural killer cell gene complex.
Advances in experimental medicine and biology
The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex.
European journal of immunology
Activating and inhibitory Ly49 receptors modulate NK cell chemotaxis to CXC chemokine ligand (CXCL) 10 and CXCL12.
Journal of immunology (Baltimore, Md. : 1950)
Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat.
Journal of immunology (Baltimore, Md. : 1950)
Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands.
Journal of immunology (Baltimore, Md. : 1950)
Ly49i2 is an inhibitory rat natural killer cell receptor for an MHC class Ia molecule (RT1-A1c).
European journal of immunology
Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family.
European journal of immunology
Expression of the platelet receptor GPVI confers signaling via the Fc receptor gamma -chain in response to the snake venom convulxin but not to collagen.
The Journal of biological chemistry
Characterization and molecular cloning of rat C1qRp, a receptor on NK cells.
European journal of immunology
Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d).
The Journal of experimental medicine
Molecular characterization of the rat NK cell receptor 2B4.
Molecular immunology
Functional analysis of natural killer cell receptors in the RNK-16 rat leukemic cell line.
Methods in molecular biology (Clifton, N.J.)
Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor.
Journal of immunology (Baltimore, Md. : 1950)
Inhibitory receptors alter natural killer cell interactions with target cells yet allow simultaneous killing of susceptible targets.
The Journal of experimental medicine
Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset.
European journal of immunology
Ly49A inhibitory receptors redistribute on natural killer cells during target cell interaction.
Immunology
Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity.
The Journal of experimental medicine
Alpha1/alpha2 domains of H-2D(d), but not H-2L(d), induce "missing self" reactivity in vivo--no effect of H-2L(d) on protection against NK cells expressing the inhibitory receptor Ly49G2.
European journal of immunology
Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development.
The Journal of experimental medicine
The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.
Journal of immunology (Baltimore, Md. : 1950)
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells.
The Journal of experimental medicine
Identification of an inhibitory MHC receptor on alloreactive rat natural killer cells.
Journal of immunology (Baltimore, Md. : 1950)
Natural killer cell cytolytic activity is inhibited by NKG2-A and activated by NKG2-C.
Journal of immunology (Baltimore, Md. : 1950)
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
The Journal of experimental medicine
Divergent functions of lectin-like receptors on NK cells.
Immunological reviews
An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.
The Journal of experimental medicine
NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity.
The Journal of experimental medicine
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
Journal of immunology (Baltimore, Md. : 1950)
Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules.
Journal of immunology (Baltimore, Md. : 1950)
NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium.
Journal of immunology (Baltimore, Md. : 1950)
cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6.
Journal of immunology (Baltimore, Md. : 1950)